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Curcumin: new positive results in gastrointestinal barrier maintenance

Milan, October 24th, 2017 – A new double-blind placebo-controlled human study[1] reveals that a short-term dietary curcumin-based supplementation may be helpful in the maintenance of the gastrointestinal barrier integrity and physiological strain responses during exertional heat stress. The study has been conducted independently by a team of American researchers at the High Point University (NC).

Meriva

The study examined an acute supplementation regimen, where participants ingested 5 tablets (500 mg each) of Meriva® curcumin or placebo for three days prior to exertional heat stress (EHS). This dosing strategy was selected with reference to those used in two recent clinical studies demonstrating the positive effects of Meriva® on healthy inflammatory responses to endurance cycling[2] and on reducing inflammatory cytokines in circulation.[3]

EHS was performed in a Darwin chamber (37°C/25%RH) where the participants completed 1 hour of treadmill exercise. Before the test, subjects were supplemented with the same daily dose of Meriva®. There were two major findings in this study. First, it demonstrates that dietary curcumin supplementation may reduce the rise in core temperature (Tc), mean body temperature (Tb), Heart Rate (HR) and Physiological Strain Index (PSI) during exertional heat stress. Second, it shows that these changes are accompanied by maintenance in GI barrier integrity and associated cytokine responses, as indicated by the lower circulating concentrations of Intestinal fatty acid binding protein (I-FABP) post-exercise in subjects supplemented with curcumin (58% vs 87% in the placebo group, p =0.002). These data suggest that short-term dietary curcumin supplementation may help to lower EHS risk in non-heat acclimated individuals. This study was the first to examine curcumin for potential benefits on system-level physiology responses during exertional heat stress.

Several scientific studies reveal that exercise-heat stress increases gastrointestinal damage and risk of exertional heatstroke. This happens because during prolonged endurance exercise blood flow is mainly diverted towards skeletal muscle and skin.” commented Antonella Riva, Product Research Manager IndenaThese new positive human data confirm and expand our  current findings on Meriva® in sport nutrition, thanks to its outstanding performance in the maintenance of healthy inflammatory levels related to physiological mechanisms occurring during physical activities through the protection of gastrointestinal system.”

Cosimo Palumbo, Indena Marketing Director, added: “Indena gladly provided the High Point University with Meriva® to conduct this independent study. We are pleased that our curcumin formulation, already supported for its efficacy and safety by several clinical studies, continues to stimulate researchers’ interest from all over the world. This is a matter of pride for Indena after years of dedication to seek excellence and innovation for consumers and business partners.”

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References:

[1] – Szymanski MC et al., Short-term dietary curcumin supplementation reduces gastrointestinal barrier damage and physiological strain responses during exertional heat stress J Appl Physiol, September 2017. Doi:10.1152/japplphysiol.00515.2017.

[2] – Sciberras JN et al., The effect of turmeric (Curcumin) supplementation on cytokine and inflammatory marker responses following 2 hours of endurance cycling. J Int Soc Sports Nutr 12:5, 2015.

[3] – McFarlin BK et al., Reduced inflammatory and muscle damage biomarkers following oral supplementation with bioavailable curcumin. BBA Clin 5:72-78, 2016.

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Meriva®

Meriva® is a patented delivery form of curcumin based on Indena’s proprietary Phytosome® technology, for healthy inflammatory response, joint health and eye health. Pharmacokinetic comparison studies have shown Meriva® to improve the overall curcuminoids bioavailability by about 30-fold, and significant absorption benefits; in particular, demethoxycurcumin (the most potent curcuminoid in numerous bioassays) was found to be 50-fold more bioavailable as compared to a non-formulated curcumin extract. Indena technology relies on the use of dietary adjuvants (lecithin) and is supported by 29 clinical trials on efficacy and by a robust tolerability and safety profile.

Further info on Meriva® and other Phytosomes: www.phytosomes.info

To know more about Phytosome® technology watch the video “Phytosome®: the technology explained” on the Indena YouTube channel.

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Indena Press Contacts
Cohn & Wolfe Milan
Laura Faravelli laura.faravelli@cohnwolfe.com
Lorenzo Petracco lorenzo.petracco@cohnwolfe.com
Tel.+39 02 202391

Please note that the physiological activity of the ingredient described herein is supported by the referenced clinical trial reports. Marketers of finished products containing the ingredient described herein are responsible for determining whether the claims made for such products are lawful and in compliance with the laws of the country in which they will market the products.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.



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